In 2006, Shideng Bao and colleagues published “Glioma Stem Cells Promote Radioresistance by Preferential Activation of the DNA Damage Response,” hereafter “Glioma Stem Cells,” in Nature. The study describes how cells within a glioblastoma, a type of fast-growing brain tumor, have a high expression of a protein called CD133, which is associated with neural stem cells. Among those cells with high expression of CD133, there exist many stem cells called glioma stem cells. In the paper, Bao and colleagues demonstrate that glioma stem cells are more resistant to radiation compared to other cells within a glioblastoma tumor, and that their resistance has to do with their ability to repair DNA. “Glioma Stem Cells” was one of the first studies to identify the role of glioma stem cells in resistance to radiation and laid the framework for future studies that investigated their role in tumor progression and recurrence as well as novel treatments targeting those cells.