Christine Jorgensen was a transgender woman and activist in the United States who lived during the twentieth century. She was one of the first US citizens to publicly disclose her gender transition from male to female through gender-affirming surgery and hormone replacement therapy. By 1949, when Jorgensen began her transition, few individuals had undergone gender transition. Various popular media outlets reported on Jorgensen’s gender transition and surgery, which allowed Jorgensen to educate the American public on topics such as gender identity and sexual orientation. Jorgensen authored an autobiography in 1967, which detailed the journey of her life from early childhood to the end of her forties. Although many transgender people continue to fight for acceptance and equality in the US as of 2024, Jorgensen’s advocacy and activism increased transgender awareness for the general public at a time when existing and living openly as a transgender person received little recognition and support.

Ben Barres researched neurobiology during the late twentieth and early twenty-first centuries as a professor at Stanford University School of Medicine in Stanford, California. His primary research focus was glial cells, which are the most abundant cells of the nervous system that support and protect neurons. There are many kinds of glial cells, and Barres examined their roles in the nervous system as well as in development and disease. Prior to Barres’s work, researchers believed that neurons were the primary players in brain function and that glial cells played a passive role. Barres discovered that glial cells play a key role in creating and eliminating synapses, which are the connections between nerve cells. Barres was transgender and after transitioning at age forty-three spoke frequently about sexism in science. Through his scientific research, Barres brought attention to the function of glial cells in development and disease, and through his activism he became a role model for LGBTQIA+ people in science.