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Daubert v. Merrell Dow Pharmaceuticals, Inc. (1993)
By: Alexis Abboud
| Published: May 29, 2017
In its 1993 decision Daubert v. Merrell Dow Pharmaceuticals, Inc., the US Supreme Court established the Daubert Standard for evaluating the…
LawBendectin (Trademark)Morning SicknessSedativesAbnormalities, Human
Josef Warkany (1902–1992)
By: Chanapa Tantibanchachai, Bianca Zietal
| Published: May 26, 2017
Josef Warkany studied the environmental causes of birth defects in the United States in the twentieth century. Warkany was one of the first…
Abnormalities, HumanVitamin ARetinoidsHypervitaminosiscalomel
"Congenital Club Foot in the Human Fetus" (1980), by Ernesto Ippolito and Ignacio Ponseti
By: Katherine Gandee
| Published: Mar 16, 2017
In 1980, Ernesto Ippolito and Ignacio Ponseti published their results on a histological study they performed on congenital club foot in human fetuses…
ClubfootPonseti, I. V. (Ignacio V.), 1914-2009Abnormalities, HumanHistologyHistology, Pathological
Virginia Apgar (1909–1974)
By: Carolina J. Abboud
| Published: Feb 16, 2017
Virginia Apgar worked as an obstetrical anesthesiologist, administering drugs that reduce women’s pain during childbirth, in the US in the mid-…
Apgar, Virginia, 1909-1974Apgar ScorePregnancyObstetricsChildbirth
Isidore Geoffroy Saint-Hilaire (1805-1861)
By: Jesse Potestas
| Published: Feb 11, 2017
Isidore Geoffroy Saint-Hilaire studied anatomy and congenital abnormalities in humans and other animals in nineteenth century France. Under the…
TeratologyAnimals--AbnormalitiesAbnormalities, HumanNatural historyAnatomy
Truman William Brophy (1848–1928)
By: Jillian Renee Kersten
| Published: Feb 11, 2017
Truman William Brophy developed a cleft palate surgical repair, later called the Brophy Operation, in the late nineteenth century US. The procedure…
Cleft PalateDental EducationAmerican Dental AssociationmalformationsBirth Defects
Isotretinoin (Accutane) as a Teratogen
By: Chanapa Tantibanchachai
| Published: Jul 20, 2014
Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal…
Teratogenic agentsVitamin AIsotretinoinAbnormalities, HumanTeratogens
Environment and Birth Defects (1973), by James G. Wilson
By: S. Alexandra Aston
| Published: Jun 21, 2014
Environment and Birth Defects by James Graves Wilson in the US was published in 1973. The book summarized information on the causes of malformations…
LiteratureBirth DefectsAbnormalities, HumanTeratogensTeratology
James G. Wilson's Six Principles of Teratology
By: S. Alexandra Aston
| Published: May 23, 2014
James Graves Wilson's six principles of teratology, published in 1959, guide research on teratogenic agents and their effects on developing organisms…
TeratologyAbnormalities, HumanCongenital AbnormalitiesBirth DefectsCongenital Defects
Studies of Thalidomide's Effects on Rodent Embryos from 1962-2008
By: Joanna Yang, Chanapa Tantibanchachai
| Published: Mar 07, 2014
Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early…
ContextTeratogenicity testingAbnormalities, HumanThalidomide--Side effectsThalidomide