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Dissertation: Degeneration in Miniature: History of Cell Death and Aging Research in the Twentieth Century
By: Lijing Jiang
| Published: Nov 17, 2020
Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in…
Cell DeathCells--AgingCaenorhabditis elegansAging, CellCellular Aging
HeLa Cell Line
By: Rohini Nott
| Published: Sep 18, 2020
The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks…
HeLa CellsContinuous cell linesResearch EthicsInformed consent (Medical law)Cervix uteri--Cancer
Apoptosis in Embryonic Development
By: Zane Bartlett
| Published: Jun 08, 2017
Apoptosis, or programmed cell death, is a mechanism in embryonic development that occurs naturally in organisms. Apoptosis is a different process…
ApoptosisGenetic regulationCaenorhabditis elegansCellsGerm Cells
The Hayflick Limit
By: Zane Bartlett
| Published: Nov 14, 2014
The Hayflick Limit is a concept that helps to explain the mechanisms behind cellular aging. The concept states that a normal human cell can only…
CellsCell populationsCell DeathApoptosisCell Proliferation
Leonard Hayflick (1928- )
By: Zane Bartlett
| Published: Jul 20, 2014
Leonard Hayflick studied the processes by which cells age during the twentieth and twenty-first centuries in the United States. In 1961 at the Wistar…
PeopleCellsCell populationsCell DeathApoptosis
"Cellular death in morphogenesis of the avian wing" (1962), by John W. Saunders Jr., et al.
By: Lijing Jiang
| Published: Mar 07, 2014
In the early 1960s, John W. Saunders Jr., Mary T. Gasseling, and Lilyan C. Saunders in the US investigated how cells die in the developing limbs of…
Cell DeathChickens--EmbryosApoptosisExperiments
Alexis Carrel's Immortal Chick Heart Tissue Cultures (1912-1946)
By: Lijing Jiang
| Published: Jul 03, 2012
In an effort to develop tissue culture techniques for long-term tissue cultivation, French surgeon and biologist Alexis Carrel, and his associates,…
Carrel, Alexis, 1873-1944Tissue cultureCellsGerm CellsEmbryos
The Discovery of p53 Protein
By: Lijing Jiang
| Published: Jan 21, 2011
The p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis,…
Tumor Suppressor Protein p53ExperimentsCancerCell Death
"Apoptosis: A Basic Biological Phenomenon with Wide-Ranging Implications in Tissue Kinetics" (1972), by John F. R. Kerr, Andrew H. Wyllie and Alastair R. Currie
By: Lijing Jiang
| Published: Jan 21, 2011
"Apoptosis: A Basic Biological Phenomenon with Wide-Ranging Implications in Tissue Kinetics" (hereafter abbreviated as "Apoptosis") was published in…
LiteratureApoptosisPublicationsCancerCell Death
"Cell Deaths in Normal Vertebrate Ontogeny" (1951), by Alfred Glücksmann
By: Lijing Jiang
| Published: Dec 06, 2010
The review article “Cell Deaths in Normal Vertebrate Ontogeny” (abbreviated as “Cell Deaths”) was published in Biological Reviews of the Cambridge…
LiteratureCell DeathPublicationsVertebratesOntogeny